Careers

Position:          Medicinal Chemistry Scientist or Senior Scientist

Carmot Therapeutics, Inc. is a biotechnology company headquartered in Berkeley, California.  We are focused on the discovery and development of novel drugs for the treatment of metabolic diseases, cancer, and inflammation. Carmot is applying an innovative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and identify superior drug candidates for challenging therapeutic targets. With multiple discovery programs and partnerships, Carmot is seeking a versatile and creative scientist to join the Chemistry team.

Position Summary:

In this research position you will play a key role in discovering and advancing compounds for the treatment of major human diseases. Your job will be to advance the early leads generated by Chemotype Evolution to clinical candidates. You should have a passion for medicinal chemistry and a willingness to innovate, and should enjoy and excel at making molecules using modern methods of organic synthesis. Experience with peptides or peptidomimetics is a plus but not essential. You will be working closely with other scientists in biochemistry and biology as part of a multidisciplinary team and will have to integrate diverse chemical and biological data to accelerate lead discovery. You will be working in a fast-paced environment and must be motivated by novel challenges, inspired by the deployment of creative solutions, and dedicated to generating high-quality data.

Primary responsibilities:

  • Compound design, synthesis, and lead optimization
  • Collaboratively set chemistry objectives to advance drug discovery programs
  • Contribute to departmental strategies as a member of the chemistry team
  • Research planning and experimental design to meet rigorous timelines
  • Presentation of research programs at team meetings, company meetings, and communication with external advisors

Required experience and skills:

  • PhD in Chemistry with 3+ years of medicinal chemistry experience
  • Excellent experimental skills and passion for working at the bench
  • Superb analytical skills and expertise in compound synthesis and characterization
  • Excellent data analysis skills and strong verbal and written communication skills
  • Ability to multitask, be well-organized and manage multiple overlapping deadlines
  • Strong interpersonal skills and the ability and expertise to work within a multi-disciplinary team
  • Candidates must be able to work independently and have demonstrated research productivity by a track record of publications, patents and/or success in industry
  • High degree of scientific intuition and a zest for discovery!

Carmot offers competitive salary, participation in our stock option plan, and comprehensive benefits. This position is located at our Berkeley site. To apply, please forward your resume and contact information to careers@carmot.us and include “Chem 171” in the subject line. Carmot is an equal opportunity employer.

 

 

Position:  Senior Scientist or Director of Pre-Clinical Sciences

Carmot Therapeutics, Inc. is a biotechnology company focused on the discovery and development of innovative drugs for the treatment of metabolic diseases, cancer, and inflammation.  Carmot is applying a transformative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and to identify superior drug candidates for challenging therapeutic targets.  Carmot is advancing multiple programs toward clinical development and is seeking an ambitious and experienced scientist to lead non-clinical pharmacology, toxicology, and IND-enabling studies.

Position Summary:

In this position, you will manage in-house and out-sourced IND-enabling studies with direct responsibility for design and execution of pharmacology and toxicology studies.  You will work closely with a team of in-house scientists and consultants to develop and manage IND-filing timelines.  An important part of the job includes identification, selection and management of CROs.  You will also be expected to participate in the design and execution of pharmacology studies to support MOA characterization, biomarker development, and clinical dose prediction.  Candidates should have a passion for drug development with extensive experience in IND-filing and early clinical development.  Carmot is a fast-paced environment and you must be excellent at multi-tasking, as you will be working with multiple internal and external resources toward a common goal.

Primary responsibilities:

  • Design and execution of pharmacology, DMPK, and toxicology studies to support IND-filing
  • Identify and select CROs to support IND-filing and non-clinical pharmacology
  • Conduct gap analysis and assist with identifying resources to complete IND-enabling studies on time
  • Develop project timelines and manage internal and external resources

Required experience and skills:

  • PhD in pharmacology, toxicology or related field with 10+ years of post-graduate experience
  • Extensive experience with IND-enabling studies and regulatory filings
  • At least five years of industry experience with transition of therapeutics from pre-clinical stage through phase 2 clinical trials
  • Experience with DMPK and early drug development in metabolic disease, inflammation and oncology
  • Excellent project management and collaboration skills and experience in managing CROs
  • Strong verbal and written communication skills and ability to multitask

 

To apply, please forward your CV, research summary, and contact information to careers@carmot.us and put “Bio 171” in the subject line.  Carmot is an equal opportunity employer.