Position:  Senior Scientist or Director of Pre-Clinical Sciences

Carmot Therapeutics, Inc. is a biotechnology company focused on the discovery and development of innovative drugs for the treatment of metabolic diseases, cancer, and inflammation.  Carmot is applying a transformative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and to identify superior drug candidates for challenging therapeutic targets.  Carmot is advancing multiple programs toward clinical development and is seeking an ambitious and experienced scientist to lead non-clinical pharmacology, toxicology, and IND-enabling studies.

Position Summary:

In this position, you will manage in-house and out-sourced IND-enabling studies with direct responsibility for design and execution of pharmacology and toxicology studies.  You will work closely with a team of in-house scientists and consultants to develop and manage IND-filing timelines.  An important part of the job includes identification, selection and management of CROs.  You will also be expected to participate in the design and execution of pharmacology studies to support MOA characterization, biomarker development, and clinical dose prediction.  Candidates should have a passion for drug development with extensive experience in IND-filing and early clinical development.  Carmot is a fast-paced environment and you must be excellent at multi-tasking, as you will be working with multiple internal and external resources toward a common goal.

Primary responsibilities:

  • Design and execution of pharmacology, DMPK, and toxicology studies to support IND-filing
  • Identify and select CROs to support IND-filing and non-clinical pharmacology
  • Conduct gap analysis and assist with identifying resources to complete IND-enabling studies on time
  • Develop project timelines and manage internal and external resources

Required experience and skills:

  • PhD in pharmacology, toxicology or related field with 10+ years of post-graduate experience
  • Extensive experience with IND-enabling studies and regulatory filings
  • At least five years of industry experience with transition of therapeutics from pre-clinical stage through phase 2 clinical trials
  • Experience with DMPK and early drug development in metabolic disease, inflammation and oncology
  • Excellent project management and collaboration skills and experience in managing CROs
  • Strong verbal and written communication skills and ability to multitask


To apply, please forward your CV, research summary, and contact information to and put “Bio 171” in the subject line.  Carmot is an equal opportunity employer.